WA Spannuth is a Fellow in the Departments of Gynecologic Oncology and Cancer Biology, AK Sood is Professor in the Departments of Gynecologic Oncology and Cancer Biology and Director of Ovarian Cancer Research, and RL Coleman is Professor and Director of Clinical Research in the Department of Gynecologic Oncology, at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Angiogenesis is a complex and highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This Review highlights the results of the latest clinical studies of antivascular agents in ovarian cancer and discusses the challenges and opportunities for future clinical trials.
PMID: 18268546 [PubMed - as supplied by publisher]
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment